Acromesomelic dysplasia, Grebe type is a rare genetic disorder characterized by short stature, skeletal abnormalities, and facial dysmorphism. It is caused by a mutation in the TRIP11 gene, which is responsible for the production of a protein involved in the development of bones and cartilage. Symptoms of this disorder include short stature, short limbs, and a distinctive facial appearance with a prominent forehead, deep-set eyes, and a small chin. Other features may include joint contractures, scoliosis, and hearing loss. Treatment is supportive and may include physical therapy, orthopedic surgery, and hearing aids.