Acrofrontofacionasal dysostosis is a rare genetic disorder characterized by abnormalities of the face, skull, and hands. It is caused by a mutation in the FGFR2 gene, which is responsible for the development of the face, skull, and hands. Symptoms of this disorder include a wide forehead, a flat midface, a short nose, a small lower jaw, and malformed hands and feet. Other features may include hearing loss, cleft palate, and intellectual disability. Treatment is based on the individual's symptoms and may include surgery, physical therapy, and speech therapy.