Acrofacial dysostosis, Kennedy-Teebi type is a rare genetic disorder characterized by facial abnormalities, skeletal malformations, and intellectual disability. It is caused by a mutation in the gene encoding the transcription factor TBX1. Symptoms may include cleft lip and/or palate, low-set ears, wide-set eyes, and a small lower jaw. Other features may include hearing loss, heart defects, and kidney abnormalities. Treatment is based on the individual's symptoms and may include surgery, speech therapy, and physical therapy.