Acro-renal-mandibular syndrome is a rare genetic disorder characterized by abnormalities of the head and face, kidneys, and hands and feet. It is caused by a mutation in the gene encoding the protein filamin A. Symptoms may include cleft lip and palate, low-set ears, wide-set eyes, a small lower jaw, and webbing of the fingers and toes. Other features may include kidney abnormalities, hearing loss, and developmental delays. Treatment is based on the individual's symptoms and may include surgery, physical therapy, and speech therapy.