Acral self-healing collodion baby is a rare skin disorder that is caused by a genetic mutation. The exact cause of the mutation is unknown, but it is believed to be related to a defect in the gene that controls the production of a protein called keratin. This protein is responsible for the formation of the outer layer of the skin. Without it, the skin becomes dry and scaly, and can easily crack and peel. Other possible causes of Acral self-healing collodion baby include environmental factors, such as exposure to certain chemicals or ultraviolet light, and certain medications.