About Acral peeling skin syndrome
What is Acral peeling skin syndrome?
Acral peeling skin syndrome (APSS) is a rare genetic disorder characterized by recurrent episodes of peeling of the skin on the palms of the hands and soles of the feet. It is caused by mutations in the TGM5 gene, which is responsible for producing an enzyme called transglutaminase 5. This enzyme is involved in the formation of the skin's outermost layer, the stratum corneum. Symptoms of APSS usually begin in infancy or early childhood and can include redness, swelling, and blistering of the skin on the palms and soles, followed by peeling of the skin. In some cases, the skin may become thickened and hyperpigmented. Treatment for APSS is typically supportive and may include topical corticosteroids, moisturizers, and antibiotics.
What are the symptoms of Acral peeling skin syndrome?
The main symptom of Acral Peeling skin syndrome is recurrent episodes of peeling of the skin on the palms of the hands and soles of the feet. Other symptoms may include:
- Dry, scaly skin
- Itching
- Redness
- Blisters
- Cracking of the skin
- Thickening of the skin
- Painful fissures
- Hyperpigmentation
- Nail changes, such as ridging, splitting, and discoloration
What are the causes of Acral peeling skin syndrome?
The exact cause of Acral peeling skin syndrome is unknown. However, it is believed to be an inherited disorder caused by a genetic mutation. It is also thought to be caused by an autoimmune disorder, where the body's immune system mistakenly attacks healthy skin cells. Other possible causes include environmental factors, such as exposure to certain chemicals or ultraviolet light.
What are the treatments for Acral peeling skin syndrome?
The main treatment for Acral peeling skin syndrome is to keep the affected skin moisturized and protected from further damage. This can be done by using a moisturizing cream or ointment, avoiding harsh soaps and detergents, and wearing protective clothing and gloves when necessary. In some cases, topical corticosteroids may be prescribed to reduce inflammation and itching. In severe cases, oral medications such as antibiotics or antifungals may be prescribed. In addition, laser therapy may be used to reduce the appearance of the affected skin.
What are the risk factors for Acral peeling skin syndrome?
The exact cause of Acral peeling skin syndrome is unknown, but there are several risk factors that may increase the likelihood of developing the condition. These include:
• Genetic predisposition: Acral peeling skin syndrome is an inherited disorder, so those with a family history of the condition are more likely to develop it.
• Exposure to certain chemicals: Exposure to certain chemicals, such as solvents, detergents, and other irritants, may increase the risk of developing Acral peeling skin syndrome.
• Certain medical conditions: Certain medical conditions, such as diabetes, psoriasis, and eczema, may increase the risk of developing Acral peeling skin syndrome.
• Age: Acral peeling skin syndrome is more common in children and young adults.
Is there a cure/medications for Acral peeling skin syndrome?
There is no known cure for Acral peeling skin syndrome. Treatment is focused on managing the symptoms and preventing infection. This may include the use of topical corticosteroids, antibiotics, and moisturizers to reduce inflammation and itching. In some cases, oral medications such as antihistamines and immunosuppressants may be prescribed.