About Acquired von Willebrand syndrome

What is Acquired von Willebrand syndrome?

Acquired von Willebrand syndrome (AVWS) is a rare bleeding disorder caused by an underlying medical condition, such as cancer, autoimmune disease, or certain medications. It is characterized by a deficiency in von Willebrand factor (VWF), a protein that helps the blood to clot. People with AVWS may experience excessive bleeding from minor cuts or injuries, as well as heavy menstrual bleeding and prolonged bleeding after surgery or dental procedures. Treatment typically involves replacing the missing VWF with a medication or transfusion.

What are the symptoms of Acquired von Willebrand syndrome?

The symptoms of Acquired von Willebrand Syndrome (AVWS) vary depending on the underlying cause, but may include:

- Easy bruising

- Excessive bleeding from cuts or injuries

- Prolonged bleeding from dental procedures

- Heavy menstrual bleeding

- Nosebleeds

- Blood in the urine or stool

- Excessive bleeding after surgery

- Unexplained bleeding in the brain or other organs

- Blood clots in the veins or arteries

What are the causes of Acquired von Willebrand syndrome?

The causes of Acquired von Willebrand Syndrome (AVWS) are not fully understood. However, it is believed to be caused by an underlying medical condition, such as an autoimmune disorder, cancer, or certain medications. Other possible causes include liver disease, kidney disease, and certain infections.

What are the treatments for Acquired von Willebrand syndrome?

1. Desmopressin (DDAVP): This is a synthetic hormone that helps to increase the levels of von Willebrand factor in the blood.

2. Tranexamic acid: This is an antifibrinolytic drug that helps to reduce bleeding by blocking the breakdown of clotting factors.

3. Platelet transfusions: Platelets are blood cells that help with clotting. Transfusions of platelets can help to reduce bleeding in people with Acquired von Willebrand syndrome.

4. Antifibrinolytic drugs: These drugs help to reduce bleeding by blocking the breakdown of clotting factors.

5. Factor VIII concentrate: This is a medication that helps to increase the levels of von Willebrand factor in the blood.

6. Immunosuppressive drugs: These

What are the risk factors for Acquired von Willebrand syndrome?

1. Certain medications, such as aspirin, ibuprofen, and other nonsteroidal anti-inflammatory drugs (NSAIDs)
2. Certain autoimmune diseases, such as lupus, rheumatoid arthritis, and Sjogren’s syndrome
3. Certain infections, such as HIV, hepatitis C, and Epstein-Barr virus
4. Certain cancers, such as lymphoma and leukemia
5. Certain blood disorders, such as thrombocytopenia and hemophilia
6. Certain genetic disorders, such as Down syndrome and Turner syndrome
7. Certain surgeries, such as heart bypass surgery and organ transplantation
8. Certain blood transfusions, such as platelet transfusions

Is there a cure/medications for Acquired von Willebrand syndrome?

At this time, there is no cure for Acquired von Willebrand Syndrome (AVWS). However, there are medications that can help manage the symptoms of AVWS. These medications include desmopressin (DDAVP), antifibrinolytic agents, and factor VIII concentrates. Your doctor can help you determine which medication is best for you.