Acquired generalized lipodystrophy (AGL) is a rare disorder characterized by the sudden and progressive loss of fat from the face, arms, legs, and trunk. It is caused by an autoimmune disorder in which the body's own immune system attacks and destroys the fat cells. Symptoms of AGL include thinning of the skin, muscle wasting, and a decrease in the amount of fat in the body. In some cases, AGL can also cause diabetes, high cholesterol, and other metabolic disorders. Treatment for AGL is focused on managing the symptoms and preventing further fat loss.