Acquired factor XIII deficiency is a rare bleeding disorder caused by a lack of factor XIII, a protein in the blood that helps the blood to clot. It is usually caused by an autoimmune disorder, in which the body's immune system mistakenly attacks and destroys the factor XIII protein. Symptoms of acquired factor XIII deficiency include excessive bleeding from cuts or injuries, nosebleeds, and heavy menstrual bleeding. Treatment typically involves replacing the missing factor XIII with a blood transfusion or a medication called NovoSeven.

The symptoms of Acquired factor XIII deficiency can vary depending on the severity of the deficiency. Common symptoms include:

- Prolonged bleeding after surgery, trauma, or childbirth
- Easy bruising
- Excessive bleeding from the gums or nose
- Heavy menstrual bleeding
- Blood in the urine or stool
- Unexplained bleeding in the brain or other organs
- Anemia due to chronic blood loss

The most common cause of acquired factor XIII deficiency is autoimmune disease, in which the body's immune system mistakenly attacks and destroys the factor XIII protein. Other causes include liver disease, certain medications, and certain genetic disorders.

The main treatment for acquired factor XIII deficiency is replacement therapy with a factor XIII concentrate. This is usually given as a single dose, but may need to be repeated if the deficiency is severe or recurrent. Other treatments may include antifibrinolytic agents such as tranexamic acid or aminocaproic acid, which can help to reduce bleeding episodes. In some cases, a blood transfusion may be necessary.

1. Liver disease
2. Kidney disease
3. Malignancy
4. Autoimmune disorders
5. Certain medications
6. Alcoholism
7. Vitamin K deficiency
8. Malnutrition
9. Hypothyroidism
10. Pregnancy

Yes, there is a treatment for Acquired Factor XIII deficiency. The treatment involves replacing the missing Factor XIII with a concentrate of Factor XIII derived from human plasma. This is usually done through a series of infusions. In some cases, medications such as antifibrinolytics may be used to help prevent bleeding episodes.