About Acquired factor VII deficiency
What is Acquired factor VII deficiency?
Acquired factor VII deficiency is a rare bleeding disorder caused by a decrease in the amount of factor VII, a clotting factor in the blood. It is usually caused by an autoimmune disorder, in which the body's immune system mistakenly attacks and destroys the factor VII. Symptoms of acquired factor VII deficiency include excessive bleeding, easy bruising, and prolonged bleeding from cuts or surgery. Treatment typically involves replacement therapy with factor VII concentrates.
What are the symptoms of Acquired factor VII deficiency?
The symptoms of Acquired Factor VII Deficiency can vary depending on the severity of the deficiency. Common symptoms include:
- Easy bruising
- Excessive bleeding from cuts or wounds
- Prolonged bleeding from minor injuries
- Heavy menstrual bleeding
- Blood in the urine or stool
- Nosebleeds
- Joint pain
- Fatigue
- Pale skin
- Shortness of breath
- Dizziness or lightheadedness
What are the causes of Acquired factor VII deficiency?
The most common cause of acquired factor VII deficiency is liver disease, such as cirrhosis or hepatitis. Other causes include certain medications, such as anticoagulants, and autoimmune disorders, such as lupus or rheumatoid arthritis. In some cases, the cause is unknown.
What are the treatments for Acquired factor VII deficiency?
1. Replacement therapy: Replacement therapy is the main treatment for acquired factor VII deficiency. This involves giving the patient a dose of factor VII concentrate, which is a man-made form of the missing factor.
2. Vitamin K: Vitamin K is a fat-soluble vitamin that helps the body produce clotting factors. It is sometimes used to treat acquired factor VII deficiency.
3. Blood transfusions: Blood transfusions may be used to replace lost blood and help restore clotting factors.
4. Surgery: Surgery may be necessary to repair any damage caused by bleeding.
5. Medications: Medications such as antifibrinolytics may be used to help reduce bleeding.
What are the risk factors for Acquired factor VII deficiency?
1. Liver disease
2. Malnutrition
3. Certain medications, such as anticonvulsants, antibiotics, and anticoagulants
4. Alcoholism
5. Chronic kidney disease
6. Autoimmune disorders, such as lupus
7. Certain infections, such as HIV/AIDS
8. Certain genetic disorders, such as hemophilia A or B
Is there a cure/medications for Acquired factor VII deficiency?
Yes, there are treatments available for acquired factor VII deficiency. Treatment typically involves replacing the missing factor VII with a medication called recombinant factor VIIa (rFVIIa). This medication helps to restore the clotting process and can be given intravenously or subcutaneously. Other treatments may include anticoagulants, such as warfarin, to prevent further clotting.