Acquired angioedema type 1 (AAT1) is a rare, inherited disorder that causes recurrent episodes of swelling in the face, tongue, and/or throat. It is caused by a deficiency of the C1 esterase inhibitor protein, which is responsible for controlling the activity of certain enzymes in the body. Symptoms of AAT1 can include swelling of the face, tongue, and/or throat, difficulty breathing, and abdominal pain. Treatment typically involves the use of medications to reduce the swelling and prevent future episodes.

The symptoms of Acquired angioedema type 1 include:

-Swelling of the face, lips, tongue, and throat
-Difficulty breathing
-Abdominal pain
-Nausea and vomiting
-Diarrhea
-Hives
-Itching
-Swelling of the hands and feet
-Joint pain
-Fatigue
-Fever

Acquired angioedema type 1 is caused by an autoimmune reaction in which the body produces autoantibodies that attack and destroy the C1 inhibitor protein. This protein is responsible for regulating the activity of certain enzymes in the body that are involved in the inflammatory response. Common causes of acquired angioedema type 1 include certain medications, infections, and autoimmune diseases.

1. Corticosteroids: Corticosteroids are the most commonly used treatment for acquired angioedema type 1. They work by reducing inflammation and suppressing the immune system.

2. Antihistamines: Antihistamines can be used to reduce the symptoms of acquired angioedema type 1. They work by blocking the action of histamine, a chemical released by the body during an allergic reaction.

3. Immunosuppressants: Immunosuppressants are drugs that suppress the immune system. They can be used to treat acquired angioedema type 1 by reducing the body’s production of antibodies that cause the condition.

4. Plasma exchange: Plasma exchange is a procedure in which the patient’s blood is removed and replaced with donor plasma. This can help reduce the levels of antibodies

1. Allergic reactions to certain medications, such as ACE inhibitors, which are used to treat high blood pressure.

2. Allergic reactions to certain foods, such as nuts, shellfish, and eggs.

3. Infections, such as HIV or hepatitis C.

4. Autoimmune diseases, such as lupus or rheumatoid arthritis.

5. Certain genetic conditions, such as C1 inhibitor deficiency.

6. Exposure to certain environmental triggers, such as insect bites or stings.

7. Stress or emotional trauma.

8. Certain medical procedures, such as surgery or dental work.

Yes, there are medications available to treat Acquired angioedema type 1. These include medications such as C1-inhibitor concentrate, antifibrinolytic agents, and corticosteroids. Additionally, immunosuppressive agents such as cyclosporine and rituximab may be used in some cases.