Zellweger-like syndrome without peroxisomal anomalies is a rare genetic disorder characterized by severe neurological and physical abnormalities. It is caused by mutations in genes involved in the development of the brain, eyes, and other organs. Symptoms may include intellectual disability, seizures, vision and hearing loss, and movement disorders.

The symptoms of Zellweger-like syndrome without peroxisomal anomalies can vary from person to person, but may include:

-Developmental delay
-Seizures
-Feeding difficulties
-Hearing loss
-Vision problems
-Growth delays
-Muscle weakness
-Abnormal facial features
-Heart defects
-Kidney problems
-Liver problems
-Gastrointestinal problems
-Skin abnormalities
-Bone abnormalities

The causes of Zellweger-like syndrome without peroxisomal anomalies are not well understood. However, it is believed that mutations in certain genes, such as PEX1, PEX2, PEX3, PEX5, PEX6, PEX10, PEX12, PEX13, PEX14, and PEX16, may be responsible for this condition. Additionally, some cases of Zellweger-like syndrome without peroxisomal anomalies have been linked to mutations in other genes, such as PEX7, PEX11, PEX19, and PEX26.

1. Early intervention: Early intervention programs can help children with Zellweger-like syndrome without peroxisomal anomalies to reach their full potential. These programs may include physical, occupational, and speech therapy, as well as educational and behavioral interventions.

2. Nutritional support: Nutritional support is important for children with Zellweger-like syndrome without peroxisomal anomalies. This may include a special diet, vitamin and mineral supplements, and tube feeding if necessary.

3. Medications: Medications may be prescribed to help manage symptoms of Zellweger-like syndrome without peroxisomal anomalies. These may include anticonvulsants to control seizures, muscle relaxants to reduce spasticity, and medications to help with sleep.

4. Surgery: Surgery may be necessary to treat certain complications of Z

1. Maternal consanguinity
2. Advanced maternal age
3. Uniparental disomy
4. Chromosomal rearrangements
5. Mutations in the PEX1, PEX6, PEX26, PEX12, and PEX2 genes
6. Mutations in the PEX10, PEX13, PEX14, PEX16, and PEX19 genes
7. Mutations in the PEX3, PEX5, PEX7, PEX8, and PEX11 genes
8. Mutations in the PEX17, PEX22, and PEX25 genes
9. Mutations in the PEX29 gene
10. Mutations in the PEX30 gene

Unfortunately, there is no cure for Zellweger-like syndrome without peroxisomal anomalies. However, there are medications that can help manage the symptoms of the condition. These include medications to help with seizures, muscle spasms, and other neurological symptoms. Additionally, physical and occupational therapy can help improve motor skills and coordination.