Wild type ABeta2M amyloidosis is a rare form of amyloidosis caused by the accumulation of a protein called ABeta2M in the body. This protein is normally found in the blood, but in some cases, it can accumulate in the organs and tissues, leading to organ damage and other health problems. Symptoms of this condition can include fatigue, weight loss, anemia, and kidney failure. Treatment typically involves medications to reduce the amount of ABeta2M in the body, as well as lifestyle changes to reduce the risk of further accumulation.

The symptoms of Wild type ABeta2M amyloidosis vary depending on the organs affected, but may include:

-Fatigue

-Weight loss

-Muscle weakness

-Joint pain

-Numbness or Tingling in the hands and feet

-Swelling in the legs and feet

-Shortness of breath

-Heart palpitations

-Abnormal heart rhythms

-Gastrointestinal problems

-Cognitive impairment

-Depression

-Anemia

-Kidney failure

Wild type ABeta2M amyloidosis is caused by a mutation in the gene that codes for the protein ABeta2M. This mutation causes the protein to be produced in an abnormal form, which can accumulate in the body and form amyloid deposits. These deposits can cause a variety of symptoms, including kidney failure, heart failure, and neurological problems.

1. Plasma exchange: This is a procedure in which the patient's blood is removed, filtered to remove the abnormal proteins, and then returned to the patient.

2. Immunosuppressive therapy: This involves using medications to suppress the immune system and reduce inflammation.

3. Bone marrow transplant: This is a procedure in which healthy bone marrow cells are transplanted into the patient to replace the abnormal cells.

4. Gene therapy: This involves introducing a healthy gene into the patient's cells to replace the defective gene.

5. Stem cell transplant: This is a procedure in which stem cells are transplanted into the patient to replace the abnormal cells.

6. Diet and lifestyle changes: This involves making changes to the patient's diet and lifestyle to reduce inflammation and improve overall health.

1. Age: Wild type ABeta2M amyloidosis is more common in people over the age of 60.

2. Gender: Wild type ABeta2M amyloidosis is more common in men than in women.

3. Genetics: Wild type ABeta2M amyloidosis is caused by a mutation in the TTR gene, which is inherited from a parent.

4. Ethnicity: Wild type ABeta2M amyloidosis is more common in people of African, Caribbean, and Mediterranean descent.

5. Medical history: People with certain medical conditions, such as diabetes, kidney disease, and heart disease, may be at an increased risk for developing Wild type ABeta2M amyloidosis.

At this time, there is no cure for Wild type ABeta2M amyloidosis. However, there are medications that can help manage the symptoms of the condition. These include medications to reduce inflammation, such as non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and immunosuppressants. Other medications may be used to reduce the amount of protein in the blood, such as diuretics and ACE inhibitors. Additionally, lifestyle changes, such as a low-salt diet and regular exercise, can help manage symptoms.