About Vein of Galen aneurysmal malformation

What is Vein of Galen aneurysmal malformation?

Vein of Galen aneurysmal malformation (VGAM) is a rare congenital vascular disorder in which a large, abnormal dilation of the vein of Galen, a major vein in the brain, occurs. This malformation can cause increased pressure in the brain, leading to a variety of neurological symptoms, including seizures, hydrocephalus, and developmental delays. Treatment typically involves surgical intervention to reduce the pressure in the brain.

What are the symptoms of Vein of Galen aneurysmal malformation?

The most common symptoms of Vein of Galen aneurysmal malformation include:

- Rapid breathing
- Poor feeding
- Poor weight gain
- Seizures
- Bulging fontanelle (soft spot on the head)
- Swelling of the head
- High-pitched cry
- Abnormal eye movements
- Abnormal head shape
- Abnormal heart rate
- Abnormal breathing pattern
- Abnormal blood pressure
- Abnormal body temperature
- Abnormal reflexes
- Abnormal muscle tone
- Abnormal skin color

What are the causes of Vein of Galen aneurysmal malformation?

Vein of Galen aneurysmal malformation (VGAM) is a rare congenital vascular malformation of the brain. It is caused by a failure of the vein of Galen to close properly during fetal development. This results in an abnormal connection between the arterial and venous systems of the brain, leading to an increased flow of blood through the vein of Galen. This increased flow can cause the vein to expand and form an aneurysm. Other possible causes of VGAM include genetic mutations, environmental factors, and abnormal fetal development.

What are the treatments for Vein of Galen aneurysmal malformation?

1. Endovascular embolization: This is a minimally invasive procedure that involves the insertion of a catheter into the vein of Galen and the injection of a special material to block the flow of blood to the aneurysm.

2. Surgical clipping: This is a more invasive procedure that involves the use of a clip to close off the aneurysm.

3. Radiosurgery: This is a non-invasive procedure that uses high-energy radiation to target and destroy the aneurysm.

4. Shunt placement: This is a procedure that involves the placement of a shunt to divert the flow of blood away from the aneurysm.

What are the risk factors for Vein of Galen aneurysmal malformation?

1. Prematurity
2. Low birth weight
3. Genetic mutations
4. Chromosomal abnormalities
5. Maternal diabetes
6. Maternal hypertension
7. Maternal drug use
8. Maternal smoking
9. Maternal alcohol use
10. Family history of Vein of Galen aneurysmal malformation

Is there a cure/medications for Vein of Galen aneurysmal malformation?

At this time, there is no cure for Vein of Galen aneurysmal malformation. Treatment options include medications to reduce the pressure in the brain, surgery to close off the malformation, and embolization to block the flow of blood to the malformation.