About Thrombotic Thrombocytopenic Purpura

What is Thrombotic Thrombocytopenic Purpura?

Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder in which blood clots form in small blood vessels throughout the body. This can lead to a low platelet count (thrombocytopenia) and a shortage of red blood cells (anemia). Symptoms of TTP include fever, fatigue, confusion, and bruising or bleeding. Treatment typically involves medications to reduce the formation of blood clots and to replace lost blood cells.

What are the symptoms of Thrombotic Thrombocytopenic Purpura?

The symptoms of Thrombotic Thrombocytopenic Purpura (TTP) can vary from person to person, but may include:

-Fever

-Fatigue
-Headache
-Confusion
-Abdominal pain
-Nausea and vomiting
-Dark urine
-Jaundice (yellowing of the skin and eyes)
-Easy bruising or bleeding
-Pale skin
-Shortness of breath
-Rapid heart rate
-Swelling in the legs and feet

What are the causes of Thrombotic Thrombocytopenic Purpura?

The exact cause of thrombotic thrombocytopenic purpura (TTP) is unknown. However, it is believed to be caused by an abnormal response of the immune system, which leads to the formation of small clots in the small blood vessels throughout the body. Possible triggers of TTP include certain medications, infections, pregnancy, and autoimmune disorders.

What are the treatments for Thrombotic Thrombocytopenic Purpura?

1. Plasma exchange (plasmapheresis): This is the most common treatment for TTP. It involves removing the patient's blood and replacing it with donor plasma. This helps to reduce the amount of abnormal proteins in the blood and can help to restore normal platelet levels.

2. Corticosteroids: Corticosteroids, such as prednisone, can help to reduce inflammation and improve platelet levels.

3. Immunosuppressants: Immunosuppressants, such as cyclosporine, can help to reduce the body's immune response and improve platelet levels.

4. Intravenous immunoglobulin (IVIG): IVIG is a blood product that contains antibodies from healthy donors. It can help to reduce the body's immune response and improve platelet levels.

5

What are the risk factors for Thrombotic Thrombocytopenic Purpura?

1. Certain medications, such as quinine, ticlopidine, clopidogrel, and heparin
2. Pregnancy
3. Cancer
4. Autoimmune disorders, such as lupus
5. Infections, such as HIV, Epstein-Barr virus, and cytomegalovirus
6. Genetic predisposition
7. Kidney disease
8. Transfusions of blood products
9. Surgery
10. Exposure to toxins

Is there a cure/medications for Thrombotic Thrombocytopenic Purpura?

Yes, there are treatments available for Thrombotic Thrombocytopenic Purpura (TTP). Treatment typically involves a combination of medications, such as corticosteroids, immunosuppressants, and plasma exchange. In some cases, surgery may be necessary to remove a clot or to repair a damaged blood vessel.