Temple syndrome is a rare genetic disorder caused by a microdeletion of the paternal chromosome 14q32.2. It is characterized by a variety of physical and developmental abnormalities, including facial dysmorphism, intellectual disability, and growth retardation.

The symptoms of Temple syndrome due to paternal 14q32.2 microdeletion can vary from person to person, but may include:

-Developmental delay
-Intellectual disability
-Speech delay
-Seizures
-Autism spectrum disorder
-Behavioral problems
-Growth delays
-Feeding difficulties
-Hypotonia
-Abnormal facial features
-Hearing loss
-Vision problems
-Heart defects
-Kidney abnormalities
-Gastrointestinal issues

Temple syndrome due to paternal 14q32.2 microdeletion is caused by a deletion of genetic material on the long arm of chromosome 14. This deletion affects the expression of several genes, including those involved in the development of the face, eyes, and brain. Symptoms of Temple syndrome include facial dysmorphism, intellectual disability, and seizures. Other associated features may include hearing loss, vision problems, and skeletal abnormalities.

Treatment for Temple syndrome due to paternal 14q32.2 microdeletion is largely supportive and symptomatic. Treatment may include physical therapy, occupational therapy, speech therapy, and/or behavioral therapy to help manage the physical and cognitive impairments associated with the condition. In some cases, medications may be prescribed to help manage seizures, sleep disturbances, and/or behavioral issues. Surgery may be recommended to correct certain physical abnormalities, such as cleft lip or palate. Genetic counseling may also be recommended to help families understand the condition and its implications.

1. Intellectual disability
2. Developmental delay
3. Speech and language delay
4. Autistic features
5. Seizures
6. Abnormal facial features
7. Abnormalities of the hands and feet
8. Abnormalities of the eyes
9. Abnormalities of the ears
10. Abnormalities of the heart
11. Abnormalities of the kidneys
12. Abnormalities of the gastrointestinal tract
13. Abnormalities of the reproductive system
14. Abnormalities of the skeletal system
15. Abnormalities of the immune system
16. Abnormalities of the endocrine system
17. Abnormalities of the nervous system
18. Abnormalities of the skin

At this time, there is no known cure or specific medications for Temple syndrome due to paternal 14q32.2 microdeletion. Treatment is focused on managing the symptoms of the condition, which can include physical, developmental, and behavioral issues. Treatment may include physical therapy, occupational therapy, speech therapy, and behavioral therapy. Medications may also be prescribed to help manage any associated medical conditions, such as seizures or sleep disturbances.