Symphalangism with multiple anomalies of hands and feet is a rare congenital disorder characterized by the fusion of two or more bones in the hands and feet. This condition can cause a range of physical deformities, including webbed fingers and toes, fused joints, and missing or extra digits. It can also cause difficulty with movement and mobility.

The symptoms of Symphalangism with multiple anomalies of hands and feet can vary depending on the severity of the condition. Common symptoms include:

-Fused fingers and toes
-Underdeveloped or absent thumbs
-Underdeveloped or absent big toes
-Underdeveloped or absent little toes
-Underdeveloped or absent nails
-Underdeveloped or absent joints
-Underdeveloped or absent muscles
-Underdeveloped or absent tendons
-Underdeveloped or absent ligaments
-Underdeveloped or absent bones
-Underdeveloped or absent skin
-Underdeveloped or absent cartilage
-Underdeveloped or absent joints
-Underdeveloped or absent tendons
-Underdeveloped or absent ligaments
-Underdeveloped or absent muscles
-Underdeveloped or absent bones
-Underdeveloped or absent skin
-Underdeveloped or absent cartilage
-Underdeveloped

Symphalangism with multiple anomalies of hands and feet is a rare congenital disorder caused by a genetic mutation. It is usually caused by a mutation in the HOXD13 gene, which is responsible for the development of the limbs. Other causes may include chromosomal abnormalities, such as trisomy 13 or 18, or a mutation in the NOG gene.

Treatment for symphalangism with multiple anomalies of hands and feet depends on the severity of the condition and the individual's specific needs. Treatment may include physical therapy, occupational therapy, and/or surgery. Physical therapy can help improve range of motion, strength, and coordination. Occupational therapy can help with activities of daily living, such as dressing, bathing, and eating. Surgery may be necessary to correct any deformities or to improve function.

1. Genetic mutations: Symphalangism with multiple anomalies of hands and feet is caused by genetic mutations in the HOXD13 gene.

2. Family history: A family history of the condition increases the risk of developing the condition.

3. Chromosomal abnormalities: Chromosomal abnormalities, such as trisomy 21 (Down syndrome) or trisomy 18 (Edwards syndrome), can increase the risk of developing Symphalangism with multiple anomalies of hands and feet.

4. Environmental factors: Exposure to certain environmental factors, such as certain medications or toxins, can increase the risk of developing the condition.

There is no cure for symphalangism with multiple anomalies of hands and feet. Treatment is focused on managing the symptoms and improving the quality of life. Treatment may include physical therapy, occupational therapy, and orthopedic surgery. Medications may be prescribed to help manage pain and inflammation.