Subcorneal pustular dermatosis (SPD) is a rare skin disorder characterized by the formation of pustules on the skin. It is an autoimmune disorder, meaning that the body's immune system mistakenly attacks healthy skin cells. Symptoms of SPD include redness, itching, and the formation of pustules on the skin. The pustules are usually filled with a yellowish fluid and may be itchy or painful. Treatment for SPD typically involves the use of topical steroids and antibiotics.

The most common symptoms of Subcorneal pustular dermatosis (SPD) include:

-Small, red, raised bumps on the skin
-Itching or Burning sensation
-Painful or tender skin
-Thick, yellow-brown crusts on the skin
-Redness and swelling around the bumps
-Blisters that may ooze or crust over
-Skin discoloration
-Thickening of the skin

The exact cause of subcorneal pustular dermatosis (SPD) is unknown. However, it is believed to be an autoimmune disorder, meaning that the body's immune system mistakenly attacks healthy cells. Other possible causes include genetic factors, certain medications, and infections.

The main treatment for Subcorneal pustular dermatosis is topical corticosteroids. Other treatments may include topical calcineurin inhibitors, systemic corticosteroids, dapsone, methotrexate, and cyclosporine. Phototherapy may also be used in some cases.

1. Female gender
2. Middle-aged or elderly age
3. History of atopic dermatitis
4. History of psoriasis
5. History of chronic skin infections
6. History of drug reactions
7. Exposure to certain medications, such as antibiotics, anticonvulsants, and nonsteroidal anti-inflammatory drugs
8. Exposure to certain chemicals, such as solvents and detergents
9. Exposure to certain metals, such as nickel and cobalt
10. Genetic predisposition

Subcorneal pustular dermatosis is a rare skin condition that is not curable. Treatment typically involves topical and/or systemic medications to reduce inflammation and control the symptoms. Common medications used to treat Subcorneal pustular dermatosis include topical corticosteroids, topical calcineurin inhibitors, systemic retinoids, and systemic immunosuppressants.