The most common symptoms of Stickler Syndrome type 1 include:

-Cleft palate
-High, arched palate
-Conductive hearing loss
-Eye problems such as myopia, cataracts, and glaucoma
-Joint problems such as hypermobility, flat feet, and early onset arthritis
-Facial features such as a small chin, a short nose, and a flat midface
-Dental problems such as crowded teeth and malocclusion
-Speech and language delays
-Developmental delays
-Scoliosis
-Heart defects
-Kidney problems

Stickler syndrome type 1 is caused by mutations in the COL2A1 gene. This gene provides instructions for making a protein called type II collagen, which is found in many tissues throughout the body, including the eyes, ears, bones, and joints. Mutations in the COL2A1 gene can lead to the production of an abnormal form of type II collagen, which can cause the signs and symptoms of Stickler syndrome type 1.

The treatments for Stickler Syndrome type 1 vary depending on the severity of the condition and the individual's symptoms. Generally, the treatments focus on managing the symptoms and preventing further complications. These treatments may include:

1. Vision correction: This may include glasses, contact lenses, or surgery to correct vision problems.

2. Hearing aids: These can help improve hearing in those with hearing loss.

3. Physical therapy: This can help improve joint flexibility and range of motion.

4. Surgery: This may be necessary to correct joint problems or to repair cleft palate.

5. Medications: These may be used to reduce inflammation and pain.

6. Genetic counseling: This can help individuals and families understand the condition and its implications.

1. Family history: Stickler syndrome type 1 is an inherited disorder, so having a family history of the condition increases the risk of developing it.

2. Age: Stickler syndrome type 1 is more common in children and young adults.

3. Gender: Stickler syndrome type 1 is more common in males than females.

4. Ethnicity: Stickler syndrome type 1 is more common in people of Northern European descent.

Yes, there are treatments available for Stickler Syndrome type 1. Treatment options include medications to reduce inflammation, surgery to correct eye and joint problems, and physical therapy to improve joint mobility. Additionally, genetic counseling and genetic testing may be recommended to help manage the condition.