Spontaneous periodic hypothermia is a rare medical condition in which a person's body temperature drops to abnormally low levels on a regular basis. It is usually accompanied by shivering, confusion, and fatigue. In some cases, it can lead to coma or even death. Treatment typically involves medications to regulate body temperature and lifestyle changes to reduce the frequency and severity of episodes.

The symptoms of Spontaneous Periodic Hypothermia (SPH) include:

-Feeling cold and shivering
-Low body temperature (below 35°C)
-Lethargy and fatigue
-Confusion
-Slowed heart rate
-Slowed breathing
-Loss of consciousness
-Muscle stiffness
-Abnormal movements
-Seizures
-Coma

The exact cause of spontaneous periodic hypothermia is unknown. However, some potential causes include:

1. Genetic mutations: Certain genetic mutations have been linked to spontaneous periodic hypothermia.

2. Hormonal imbalances: Imbalances in hormones such as thyroid hormones, cortisol, and growth hormone can lead to spontaneous periodic hypothermia.

3. Medications: Certain medications, such as antipsychotics and antidepressants, can cause hypothermia.

4. Infections: Infections such as HIV, hepatitis, and Lyme disease can cause hypothermia.

5. Environmental factors: Exposure to cold temperatures or extreme weather can cause hypothermia.

6. Psychological factors: Stress, anxiety, and depression can lead to hypothermia.

1. Antipyretic medications such as ibuprofen or acetaminophen
2. Antidepressants such as selective serotonin reuptake inhibitors (SSRIs)
3. Beta-blockers
4. Calcium channel blockers
5. Clonidine
6. Tricyclic antidepressants
7. Sympathomimetic agents
8. Thyroid hormone replacement therapy
9. Vitamin B12 supplementation
10. Intravenous immunoglobulin (IVIG)
11. Plasma exchange
12. Surgery to remove the affected area of the brain

1. Family history of the condition
2. Genetic mutations
3. Certain medications
4. Low body weight
5. Low thyroid hormone levels
6. Low blood sugar levels
7. Low blood pressure
8. Low body temperature
9. Exposure to cold temperatures
10. Stress or emotional trauma

There is no known cure for spontaneous periodic hypothermia. However, medications such as beta-blockers, calcium channel blockers, and serotonin reuptake inhibitors may be used to help manage the symptoms. Additionally, lifestyle modifications such as avoiding cold temperatures, wearing layers of clothing, and avoiding alcohol and caffeine may help reduce the frequency and severity of episodes.