Splenic diffuse red pulp small B-cell lymphoma (SDRP-SBL) is a rare type of non-Hodgkin lymphoma (NHL) that affects the spleen. It is a type of B-cell lymphoma, which is a type of cancer that affects the white blood cells called B-cells. SDRP-SBL is characterized by the presence of abnormal B-cells in the red pulp of the spleen. These cells can spread to other organs, such as the liver, bone marrow, and lymph nodes. Treatment typically involves chemotherapy and/or radiation therapy.

Common symptoms of Splenic diffuse red pulp small B-cell lymphoma include:

- Abdominal Pain or fullness
- Enlarged spleen (splenomegaly)
- Unexplained weight loss
- Fatigue
- Fever
- Night sweats
- Loss of appetite
- Abnormal blood counts, including low red blood cell count (anemia) and low platelet count (thrombocytopenia)
- Abnormal liver function tests

The exact cause of splenic diffuse red pulp small B-cell lymphoma is unknown. However, it is believed to be associated with a combination of genetic and environmental factors. Some of the potential risk factors include exposure to certain chemicals, such as benzene, and certain viral infections, such as Epstein-Barr virus.

The main treatment for splenic diffuse red pulp small B-cell lymphoma is chemotherapy. This may be combined with radiation therapy, depending on the stage of the disease. Other treatments may include stem cell transplantation, targeted therapy, and immunotherapy. Surgery may be used to remove the spleen if it is causing symptoms or if it is enlarged.

1. Age: Splenic diffuse red pulp small B-cell lymphoma is more common in older adults.

2. Gender: Splenic diffuse red pulp small B-cell lymphoma is more common in males than females.

3. Immunosuppression: People with weakened immune systems, such as those with HIV/AIDS, are at an increased risk of developing splenic diffuse red pulp small B-cell lymphoma.

4. Exposure to certain chemicals: Exposure to certain chemicals, such as benzene, may increase the risk of developing splenic diffuse red pulp small B-cell lymphoma.

5. Family history: People with a family history of lymphoma may be at an increased risk of developing splenic diffuse red pulp small B-cell lymphoma.

At this time, there is no known cure for splenic diffuse red pulp small B-cell lymphoma. Treatment typically involves chemotherapy and/or radiation therapy. Depending on the individual case, other treatments such as stem cell transplantation, immunotherapy, and targeted therapy may also be used.