Silver-Russell syndrome (SRS) is a rare genetic disorder characterized by slow growth before and after birth, distinctive facial features, and other physical problems. It is caused by a genetic abnormality known as maternal uniparental disomy of chromosome 11 (UPD11). UPD11 occurs when a person has two copies of chromosome 11 from the same parent, instead of one copy from each parent. This abnormality can lead to a variety of physical and developmental problems, including those seen in SRS.

The symptoms of Silver-Russell syndrome due to maternal uniparental disomy of chromosome 11 can vary from person to person, but may include:

- Low birth weight and slow growth
- Small head size (microcephaly)
- Delayed motor development
- Feeding difficulties
- Facial features such as a triangular face, prominent forehead, and thin upper lip
- Intellectual disability
- Behavioral problems
- Abnormalities of the hands and feet
- Abnormalities of the internal organs

Silver-Russell syndrome (SRS) due to maternal uniparental disomy of chromosome 11 is caused by a genetic abnormality in which a person has two copies of chromosome 11 from one parent and none from the other. This abnormality is caused by a random error in the formation of the egg or sperm, or during the early stages of embryo development. It is not inherited from either parent.

1. Growth hormone therapy: Growth hormone therapy is the most common treatment for Silver-Russell syndrome due to maternal uniparental disomy of chromosome 11. Growth hormone therapy helps to stimulate growth and can help to improve the physical features associated with Silver-Russell syndrome.

2. Nutritional therapy: Nutritional therapy is important for children with Silver-Russell syndrome due to maternal uniparental disomy of chromosome 11. This includes providing a balanced diet with adequate calories and nutrients to support growth and development.

3. Physical therapy: Physical therapy can help to improve muscle strength and coordination, as well as posture and balance.

4. Speech therapy: Speech therapy can help to improve communication skills and language development.

5. Occupational therapy: Occupational therapy can help to improve fine motor skills and daily living activities.

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1. Maternal age over 35
2. Advanced paternal age
3. Family history of Silver-Russell syndrome
4. Maternal diabetes
5. Maternal obesity
6. Maternal smoking
7. Maternal alcohol consumption
8. Maternal exposure to environmental toxins
9. Maternal stress
10. Maternal nutritional deficiencies

At this time, there is no cure for Silver-Russell syndrome due to maternal uniparental disomy of chromosome 11. However, there are medications and treatments available to help manage the symptoms of the condition. These include growth hormone therapy, nutritional supplements, and medications to help with sleep, behavior, and other issues. Additionally, physical and occupational therapy can help with motor skills and other developmental delays.