Silver-Russell syndrome (SRS) is a rare genetic disorder characterized by slow growth before and after birth, a triangular face, and a small head size. It is caused by a microduplication of genetic material on the short arm of chromosome 7 (7p11.2p13). This duplication is thought to disrupt the normal regulation of genes in the region, leading to the characteristic features of SRS.

The symptoms of Silver-Russell syndrome due to 7p11.2p13 microduplication can vary from person to person, but may include:

- Low birth weight
- Poor growth
- Delayed development
- Small head size (microcephaly)
- Unusually shaped ears
- A triangular face
- A prominent forehead
- A small lower jaw
- A narrow, high-arched palate
- A protruding tongue
- A curved fifth finger (clinodactyly)
- A wide space between the first and second toes (sandal gap)
- Intellectual disability
- Behavioral problems
- Heart defects
- Kidney abnormalities
- Vision and hearing problems

Silver-Russell syndrome (SRS) due to 7p11.2p13 microduplication is caused by a genetic mutation in which a small piece of chromosome 7 is duplicated. This duplication can cause a variety of physical and developmental abnormalities, including growth retardation, facial dysmorphism, and intellectual disability. The exact cause of this duplication is unknown, but it is believed to be due to a spontaneous mutation in the mother's egg or sperm cell. Other possible causes include environmental factors, such as exposure to certain chemicals or radiation, or a genetic predisposition.

The treatments for Silver-Russell syndrome due to 7p11.2p13 microduplication vary depending on the individual and the severity of the symptoms. Generally, treatment focuses on managing the symptoms and improving quality of life. This may include physical therapy, occupational therapy, speech therapy, nutritional counseling, and growth hormone therapy. Additionally, medications may be prescribed to help with sleep disturbances, anxiety, and other behavioral issues. Surgery may be recommended to correct physical abnormalities, such as cleft palate. Finally, psychological counseling may be recommended to help individuals and families cope with the diagnosis.

1. Low birth weight
2. Poor growth
3. Developmental delay
4. Intellectual disability
5. Facial dysmorphism
6. Skeletal abnormalities
7. Congenital heart defects
8. Kidney anomalies
9. Gastrointestinal problems
10. Hypoglycemia
11. Hypothyroidism
12. Hearing loss
13. Vision problems
14. Behavioral problems

At this time, there is no cure for Silver-Russell syndrome due to 7p11.2p13 microduplication. Treatment focuses on managing the symptoms and complications associated with the condition. Medications may be prescribed to help with growth, appetite, and behavior. Physical and occupational therapy may also be recommended to help with motor development.