Severe hereditary thrombophilia due to congenital protein C deficiency is a rare inherited disorder that affects the body's ability to control blood clotting. People with this condition have a deficiency of the protein C enzyme, which is responsible for regulating the clotting process. This deficiency can lead to an increased risk of developing blood clots in the veins (venous thrombosis) and can cause serious complications such as stroke, pulmonary embolism, and deep vein thrombosis. Treatment typically involves anticoagulant medications to reduce the risk of clotting.

The symptoms of Severe hereditary thrombophilia due to congenital protein C deficiency include:

-Recurrent deep vein thrombosis (DVT)
-Recurrent pulmonary embolism (PE)
-Recurrent superficial thrombophlebitis
-Recurrent miscarriages
-Stroke
-Heart attack
-Skin necrosis
-Livedo reticularis
-Gangrene
-Retinal vein occlusion
-Cerebral venous thrombosis

Severe hereditary thrombophilia due to congenital protein C deficiency is caused by a genetic mutation in the PROC gene, which is responsible for producing the protein C enzyme. This mutation results in a deficiency of the protein C enzyme, which is responsible for regulating the body’s clotting process. Without enough protein C, the body’s clotting process is disrupted, leading to an increased risk of blood clots.

1. Anticoagulant medications: Anticoagulant medications such as warfarin, heparin, and low-molecular-weight heparin are used to reduce the risk of blood clots in people with severe hereditary thrombophilia due to congenital protein C deficiency.

2. Replacement therapy: Replacement therapy involves giving the patient a synthetic form of protein C to replace the missing protein C. This can help reduce the risk of blood clots.

3. Lifestyle changes: Making lifestyle changes such as quitting smoking, exercising regularly, and eating a healthy diet can help reduce the risk of blood clots.

4. Surgery: In some cases, surgery may be necessary to remove a blood clot or to repair a damaged blood vessel.

1. Family history of thrombophilia
2. Personal history of thrombosis
3. Pregnancy
4. Estrogen-containing medications
5. Smoking
6. Obesity
7. Advanced age
8. Immobility
9. Surgery
10. Cancer
11. Inflammatory conditions
12. Infection
13. Dehydration
14. Trauma

Yes, there are treatments available for Severe hereditary thrombophilia due to congenital protein C deficiency. Treatment typically involves anticoagulant medications such as warfarin or heparin, as well as lifestyle changes such as avoiding smoking and maintaining a healthy weight. In some cases, a protein C concentrate may be used to replace the deficient protein C.