Secondary non-traumatic avascular necrosis (AVN) is a condition in which the bone tissue dies due to a lack of blood supply. It is usually caused by an underlying medical condition, such as diabetes, lupus, or alcohol abuse. Symptoms of AVN include pain, swelling, and stiffness in the affected area. Treatment options include medications, physical therapy, and surgery.

The symptoms of secondary non-traumatic avascular necrosis can vary depending on the underlying cause, but may include:

- Pain in the affected joint, which may worsen with activity
- Stiffness in the affected joint
- Swelling in the affected joint
- Decreased range of motion in the affected joint
- Weakness in the affected joint
- Instability in the affected joint
- Difficulty walking or bearing weight on the affected joint

The most common causes of secondary non-traumatic avascular necrosis are:

1. Excessive alcohol consumption

2. Long-term use of corticosteroids

3. Certain chemotherapy drugs

4. Radiation therapy

5. Sickle cell anemia

6. Gaucher's disease

7. Pancreatitis

8. Systemic lupus erythematosus

9. Hyperlipidemia

10. Gout

11. HIV/AIDS

12. Connective tissue disorders

13. Certain metabolic disorders

14. Certain blood disorders

15. Certain kidney disorders

16. Certain liver disorders

17. Certain heart disorders

1. Non-surgical treatments:

- Pain medications
- Corticosteroid injections
- Physical therapy
- Weight loss
- Joint protection
- Assistive devices

2. Surgical treatments:

- Core decompression
- Osteotomy
- Joint replacement
- Bone grafting
- Arthrodesis

1. Long-term use of corticosteroids
2. Excessive alcohol consumption
3. Sickle cell anemia
4. Hyperlipidemia
5. Diabetes
6. Gout
7. Radiation therapy
8. Connective tissue disorders
9. HIV/AIDS
10. Autoimmune diseases
11. Hematologic disorders
12. Trauma
13. Certain medications (such as high-dose aspirin, bisphosphonates, and antiretroviral drugs)

There is no cure for secondary non-traumatic avascular necrosis, but medications can be used to help manage the symptoms. These medications include non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and bisphosphonates. In some cases, surgery may be recommended to help reduce pain and improve joint function.