Scleroderma is a chronic autoimmune disorder that affects the connective tissue of the body. It is characterized by the hardening and tightening of the skin and connective tissues, leading to problems with movement and organ function. It can also cause inflammation and damage to the blood vessels, lungs, heart, and kidneys.

Common symptoms of scleroderma include:

-Tight, thickened, and/or hardened skin
Raynaud's phenomenon (cold, pale, and/or blue fingers or toes)
Joint Pain and stiffness
Swollen fingers and toes
Digestive problems
Fatigue
Shortness of breath
Dry eyes and mouth
Difficulty swallowing
Heartburn
High blood pressure
Kidney problems
Calcium deposits in the skin
Hair loss
Depression

The exact cause of scleroderma is unknown, but it is believed to be related to an overactive immune system. Factors that may contribute to the development of scleroderma include genetics, environmental exposures, and hormonal changes.

The treatments for Scleroderma vary depending on the type and severity of the condition. Generally, treatments may include medications to reduce inflammation, suppress the immune system, and improve blood flow; physical therapy; and lifestyle changes such as quitting smoking, eating a healthy diet, and exercising regularly. In some cases, surgery may be necessary to remove hardened areas of skin or to repair damaged organs.

1. Age: Scleroderma is most common in people between the ages of 30 and 50.
2. Gender: Women are more likely to develop scleroderma than men.
3. Race: African Americans are more likely to develop scleroderma than other races.
4. Family history: Having a family member with scleroderma increases your risk.
5. Exposure to certain chemicals: Exposure to certain chemicals, such as silica, may increase your risk of developing scleroderma.
6. Smoking: Smoking increases your risk of developing scleroderma.

There is no cure for scleroderma, but medications can help manage symptoms and slow the progression of the disease. Common medications used to treat scleroderma include immunosuppressants, corticosteroids, antimalarials, and biologics.