Rubinstein-Taybi syndrome (RTS) is a rare genetic disorder caused by a microdeletion of the 16p13.3 region of chromosome 16. It is characterized by physical abnormalities, intellectual disability, and behavioral problems. Common physical features include short stature, broad thumbs and toes, and facial abnormalities such as a prominent forehead, down-slanting eyes, and a wide mouth. Other features may include heart defects, kidney abnormalities, and skeletal malformations. Intellectual disability is usually mild to moderate, and behavioral problems may include hyperactivity, impulsivity, and aggression.

The most common symptoms of Rubinstein-Taybi syndrome due to 16p13.3 microdeletion include:

-Intellectual disability
-Developmental delay
-Distinctive facial features, including a broad forehead, down-slanting eyes, a beaked nose, and full lips
-Short stature
-Broad thumbs and first toes
-Heart defects
-Skeletal abnormalities
-Hearing loss
-Seizures
-Feeding difficulties
-Speech delays
-Behavioral problems

Rubinstein-Taybi syndrome (RTS) is a genetic disorder caused by a microdeletion of the 16p13.3 region of chromosome 16. This microdeletion affects the expression of several genes, including the CREBBP and EP300 genes, which are involved in the regulation of cell growth and development. The exact cause of the microdeletion is unknown, but it is believed to be due to a spontaneous mutation in the affected genes. Other possible causes include environmental factors, such as exposure to certain chemicals or radiation, or a genetic predisposition.

1. Physical therapy: Physical therapy can help improve muscle strength, coordination, and balance.

2. Occupational therapy: Occupational therapy can help improve fine motor skills, such as writing and drawing, as well as activities of daily living, such as dressing and eating.

3. Speech therapy: Speech therapy can help improve communication skills.

4. Behavioral therapy: Behavioral therapy can help with social skills, self-care, and problem-solving.

5. Medications: Medications can help with seizures, anxiety, and other behavioral issues.

6. Surgery: Surgery may be necessary to correct physical deformities or to treat medical conditions.

7. Genetic counseling: Genetic counseling can help families understand the condition and its implications.

1. Intellectual disability
2. Delayed development
3. Speech and language delays
4. Seizures
5. Behavioral problems
6. Abnormal facial features
7. Short stature
8. Broad thumbs and toes
9. Narrow palpebral fissures
10. Low-set ears
11. Hypoplastic nails
12. Cardiac defects
13. Hernias
14. Renal anomalies
15. Skeletal abnormalities
16. Gastrointestinal problems
17. Endocrine abnormalities
18. Hearing loss

At this time, there is no cure for Rubinstein-Taybi syndrome due to 16p13.3 microdeletion. However, there are medications and therapies that can help manage the symptoms of the condition. These include medications to help with seizures, physical and occupational therapy to help with motor skills, speech therapy to help with communication, and behavioral therapy to help with social skills.