Refractory anemia with excess blasts (RAEB) is a type of myelodysplastic syndrome (MDS) in which the bone marrow produces too many immature white blood cells (blasts) and not enough healthy red blood cells, white blood cells, and platelets. It is a type of myelodysplastic/myeloproliferative neoplasm (MDS/MPN). People with RAEB may experience fatigue, shortness of breath, and an increased risk of infection. Treatment options include chemotherapy, stem cell transplant, and supportive care.

The symptoms of Refractory Anemia with Excess Blasts (RAEB) can vary depending on the severity of the condition. Common symptoms include fatigue, shortness of breath, pale skin, easy bruising, frequent infections, and weight loss. Other symptoms may include fever, night sweats, bone pain, and an enlarged spleen.

The causes of Refractory Anemia with Excess Blasts (RAEB) can include:

1. Inherited genetic disorders, such as Fanconi Anemia, Diamond-Blackfan Anemia, and Dyskeratosis Congenita.

2. Acquired genetic disorders, such as myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).

3. Exposure to certain chemicals or radiation.

4. Certain infections, such as HIV or hepatitis.

5. Certain medications, such as chemotherapy drugs.

6. Autoimmune disorders, such as lupus or rheumatoid arthritis.

7. Vitamin B12 or folate deficiency.

8. Bone marrow failure syndromes.

1. Chemotherapy: Chemotherapy is the most common treatment for refractory anemia with excess blasts. It involves using drugs to kill the abnormal cells that are causing the anemia.

2. Bone Marrow Transplant: A bone marrow transplant is a procedure in which healthy bone marrow cells are transplanted into the patient to replace the abnormal cells.

3. Immunosuppressive Therapy: Immunosuppressive therapy is a type of treatment that uses drugs to suppress the immune system and reduce the body’s response to the abnormal cells.

4. Targeted Therapy: Targeted therapy is a type of treatment that uses drugs to target specific molecules in the abnormal cells and stop them from growing and dividing.

5. Clinical Trials: Clinical trials are research studies that test new treatments for refractory anemia with excess blasts

1. Advanced age
2. Previous chemotherapy or radiation therapy
3. Exposure to certain chemicals or toxins
4. Family history of blood disorders
5. Certain genetic mutations
6. Certain infections
7. Certain autoimmune diseases
8. Certain medications

Yes, there are treatments available for refractory anemia with excess blasts. Treatment options may include chemotherapy, stem cell transplantation, and targeted therapies. Medications used to treat refractory anemia with excess blasts may include hydroxyurea, decitabine, and lenalidomide. Your doctor will be able to discuss the best treatment option for you.