Proximal myopathy with extrapyramidal signs is a rare neurological disorder characterized by muscle weakness in the proximal muscles (those closest to the trunk of the body) and extrapyramidal signs, which are involuntary movements that can include tremors, muscle spasms, and difficulty with coordination and balance. It is caused by a variety of genetic and environmental factors, and there is no known cure. Treatment focuses on managing symptoms and improving quality of life.

The symptoms of Proximal myopathy with extrapyramidal signs can vary depending on the underlying cause, but may include:

- Muscle weakness, especially in the proximal muscles (those closest to the trunk of the body)
- Difficulty walking, climbing stairs, or rising from a seated position
- Abnormal gait
- Tremors
- Rigidity
- Slowed movements
- Difficulty with fine motor skills
- Speech difficulties
- Impaired balance
- Difficulty swallowing
- Fatigue

Proximal myopathy with extrapyramidal signs is a rare neurological disorder that is caused by a variety of genetic and environmental factors. The most common causes include:

1. Inherited genetic mutations: Certain genetic mutations can cause proximal myopathy with extrapyramidal signs. These mutations can be inherited from a parent or can occur spontaneously.

2. Environmental factors: Exposure to certain environmental toxins, such as lead, mercury, and pesticides, can increase the risk of developing proximal myopathy with extrapyramidal signs.

3. Infections: Certain viral and bacterial infections can cause proximal myopathy with extrapyramidal signs.

4. Medications: Certain medications, such as antipsychotics and anticonvulsants, can increase the risk of developing proximal myopathy with extrapyramidal signs

1. Physical therapy: Physical therapy can help improve strength, flexibility, and range of motion.

2. Medications: Medications such as baclofen, diazepam, and tizanidine can help reduce muscle spasms and improve muscle control.

3. Botulinum toxin injections: Botulinum toxin injections can help reduce muscle spasms and improve muscle control.

4. Surgery: Surgery may be recommended in some cases to help improve muscle control.

5. Assistive devices: Assistive devices such as braces, canes, and walkers can help improve mobility.

6. Diet and nutrition: Eating a healthy diet and getting adequate nutrition can help improve muscle strength and function.

1. Genetic mutations
2. Advanced age
3. Exposure to certain toxins
4. Certain medications
5. Alcoholism
6. Vitamin B12 deficiency
7. Hypothyroidism
8. Diabetes
9. HIV/AIDS
10. Autoimmune diseases

There is no cure for proximal myopathy with extrapyramidal signs, but medications can be used to manage the symptoms. These medications may include muscle relaxants, anticholinergics, and dopamine agonists. Physical therapy and lifestyle modifications, such as avoiding strenuous activities, can also help to manage the symptoms.