Primary polyarteritis nodosa (PAN) is a rare autoimmune disorder that affects the arteries. It is characterized by inflammation of the walls of medium-sized and large arteries, which can lead to narrowing or weakening of the arteries. This can cause a variety of symptoms, including fever, fatigue, weight loss, muscle and joint pain, and skin rashes. In some cases, PAN can cause serious complications, such as organ damage or stroke. Treatment typically involves medications to reduce inflammation and suppress the immune system.

The most common symptoms of primary polyarteritis nodosa (PAN) include:

-Muscle aches and pains
-Fever
-Weight loss
-Fatigue
-Abdominal pain
-Joint pain
-Skin rash
-Numbness or Tingling in the hands and feet
-High blood pressure
-Loss of appetite
-Nausea and vomiting
-Liver and kidney problems
-Shortness of breath
-Chest pain
-Heart palpitations
-Stroke-like symptoms

The exact cause of primary polyarteritis nodosa (PAN) is unknown. However, it is believed to be an autoimmune disorder, meaning that the body's immune system mistakenly attacks healthy tissue. Possible triggers for PAN include infections, certain medications, and environmental factors.

The main treatments for primary polyarteritis nodosa (PAN) are corticosteroids and immunosuppressive medications. Corticosteroids, such as prednisone, are used to reduce inflammation and suppress the immune system. Immunosuppressive medications, such as cyclophosphamide, azathioprine, and methotrexate, are used to further suppress the immune system and reduce inflammation. In some cases, plasmapheresis (a procedure that removes antibodies from the blood) may be used to reduce inflammation. In severe cases, surgery may be necessary to repair damaged arteries.

1. Male gender
2. Age between 40-50
3. Smoking
4. Exposure to certain chemicals
5. Infection with hepatitis B or C virus
6. Certain genetic factors
7. Certain autoimmune diseases, such as systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA)

Yes, there are treatments available for primary polyarteritis nodosa. Treatment typically involves medications such as corticosteroids, immunosuppressants, and biologics. In some cases, surgery may be necessary to repair damaged blood vessels.