Primary mediastinal large B-cell lymphoma (PMBCL) is a type of non-Hodgkin lymphoma (NHL) that affects the mediastinum, the area between the lungs in the chest. It is a rare type of NHL, accounting for only 1-2% of all NHL cases. PMBCL is an aggressive form of lymphoma that is characterized by the presence of large B-cells in the mediastinum. Symptoms of PMBCL may include chest pain, shortness of breath, and fever. Treatment typically involves chemotherapy and/or radiation therapy.

The most common symptoms of Primary mediastinal large B-cell lymphoma are:

-Chest pain
-Shortness of breath
-Cough
-Fatigue
-Fever
-Weight loss
-Night sweats
-Enlarged lymph nodes in the neck, armpits, or groin
-Enlarged spleen or liver
-Abdominal pain
-Difficulty swallowing

The exact cause of primary mediastinal large B-cell lymphoma is unknown. However, some risk factors have been identified, including:

• Exposure to certain chemicals, such as benzene

• Exposure to radiation

• A weakened immune system

• Certain genetic conditions, such as Li-Fraumeni syndrome

• Certain viral infections, such as Epstein-Barr virus (EBV)

The primary treatment for primary mediastinal large B-cell lymphoma is chemotherapy, usually in combination with radiation therapy. Chemotherapy drugs used to treat this type of lymphoma include cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab. In some cases, stem cell transplantation may be recommended. Other treatments may include targeted therapy, immunotherapy, and surgery.

1. Exposure to certain chemicals, such as herbicides and pesticides
2. Having a weakened immune system
3. Having a family history of lymphoma
4. Being exposed to radiation
5. Having certain genetic conditions, such as Klinefelter syndrome
6. Being infected with the Epstein-Barr virus

Yes, there are treatments available for primary mediastinal large B-cell lymphoma. Treatment options may include chemotherapy, radiation therapy, stem cell transplant, and targeted therapy. Your doctor will discuss the best treatment plan for you based on your individual situation.