Yes, there are treatments available for primary hypomagnesemia with hypercalciuria and nephrocalcinosis without severe ocular involvement. Treatment typically involves dietary modifications, such as increasing dietary magnesium intake and reducing dietary calcium intake, as well as medications to reduce calcium excretion in the urine. Additionally, medications such as thiazide diuretics, loop diuretics, and potassium citrate may be prescribed to reduce calcium excretion and increase magnesium absorption. In some cases, intravenous magnesium supplementation may be necessary.

1. Low dietary intake of magnesium
2. Low dietary intake of calcium
3. Excessive intake of vitamin D
4. Excessive intake of phosphorus
5. Excessive intake of sodium
6. Excessive intake of alcohol
7. Certain medications, such as diuretics, proton pump inhibitors, and antacids
8. Chronic kidney disease
9. Diabetes
10. Gastrointestinal disorders, such as Crohn’s disease and celiac disease
11. Certain genetic disorders, such as Bartter syndrome and Gitelman syndrome
12. Certain endocrine disorders, such as hyperparathyroidism and Cushing’s syndrome
13. Certain autoimmune disorders, such as systemic lupus erythematosus and Sjögren’s syndrome
14. Certain infections, such as HIV

1. Oral magnesium supplementation: This is the mainstay of treatment for primary hypomagnesemia with hypercalciuria and nephrocalcinosis. The goal of magnesium supplementation is to restore normal serum magnesium levels and to reduce urinary calcium excretion.

2. Dietary modifications: Dietary modifications may be necessary to reduce the amount of calcium and oxalate in the diet. This may include reducing the intake of high-calcium foods such as dairy products, nuts, and green leafy vegetables.

3. Thiazide diuretics: Thiazide diuretics may be used to reduce urinary calcium excretion.

4. Potassium citrate: Potassium citrate may be used to reduce urinary calcium excretion and to increase urinary citrate excretion.

5. Vitamin D supplementation: Vitamin D supplementation may be

1. Renal magnesium wasting due to a genetic defect in the renal tubular reabsorption of magnesium.
2. Excessive intake of calcium or vitamin D.
3. Excessive intake of diuretics or laxatives.
4. Chronic diarrhea or malabsorption syndromes.
5. Prolonged use of proton pump inhibitors.
6. Chronic kidney disease.
7. Certain medications, such as amphotericin B, cisplatin, and cyclosporine.
8. Hypoparathyroidism.
9. Hyperthyroidism.
10. Diabetes mellitus.

The symptoms of Primary hypomagnesemia with hypercalciuria and nephrocalcinosis without severe ocular involvement may include:

-Fatigue
-Muscle weakness
-Loss of appetite
-Nausea
-Vomiting
-Abdominal pain
-Frequent urination
-Excessive thirst
-Dehydration
-Confusion
-Tremors
-Seizures
-Cardiac arrhythmias
-High blood pressure
-Kidney stones
-Calcium deposits in the kidneys

Primary hypomagnesemia with hypercalciuria and nephrocalcinosis without severe ocular involvement is a rare inherited disorder caused by a mutation in the TRPM6 gene. It is characterized by low levels of magnesium in the blood, high levels of calcium in the urine, and the formation of calcium deposits in the kidneys. Symptoms may include muscle weakness, fatigue, and seizures. Treatment typically involves magnesium supplementation and dietary modifications to reduce calcium intake.