Yes, there are medications available to treat PLG-related hereditary angioedema with normal C1Inh. These medications include antifibrinolytics such as tranexamic acid, androgens such as danazol, and C1-inhibitor concentrate. Additionally, immunomodulators such as omalizumab and icatibant may be used to treat the condition.

1. Family history of PLG-related hereditary angioedema with normal C1Inh
2. Female gender
3. Age of onset before puberty
4. History of recurrent episodes of angioedema
5. Presence of other allergic conditions
6. History of recurrent abdominal pain
7. History of recurrent laryngeal edema
8. History of recurrent facial edema
9. History of recurrent joint swelling
10. History of recurrent urticaria

1. Antifibrinolytic agents such as tranexamic acid or epsilon aminocaproic acid: These agents help to reduce the breakdown of blood clots and can help to reduce the severity of attacks.

2. Antihistamines: These medications can help to reduce the symptoms of an attack, such as itching, swelling, and hives.

3. Corticosteroids: These medications can help to reduce inflammation and can be used to treat more severe attacks.

4. C1-inhibitor concentrate: This is a medication that can be used to replace the missing C1-inhibitor in the body and can help to reduce the severity of attacks.

5. Plasma-derived C1-inhibitor concentrate: This is a medication that can be used to replace

1. Mutations in the F12 gene, which encodes the coagulation factor XII.
2. Mutations in the SERPING1 gene, which encodes C1 inhibitor.
3. Mutations in the PRSS1 gene, which encodes the protease inhibitor.
4. Mutations in the HAE2 gene, which encodes the coagulation factor XI.
5. Mutations in the HAE3 gene, which encodes the coagulation factor IX.
6. Mutations in the HAE1 gene, which encodes the coagulation factor VIII.
7. Mutations in the F13A1 gene, which encodes the coagulation factor XIII.
8. Mutations in the F11 gene, which encodes the coagulation factor XI.
9. Mut

The symptoms of PLG-related hereditary angioedema with normal C1Inh include recurrent episodes of swelling of the face, lips, tongue, throat, hands, feet, and other parts of the body. These episodes can last for several hours and can be accompanied by itching, hives, abdominal pain, nausea, vomiting, and difficulty breathing. In some cases, the swelling can be severe enough to cause airway obstruction and require emergency medical attention.

PLG-related hereditary angioedema with normal C1Inh is a rare form of hereditary angioedema (HAE) caused by a mutation in the gene that encodes the protein proline-rich glycoprotein (PLG). This mutation results in a decrease in the amount of PLG produced, which in turn leads to a decrease in the activity of the enzyme C1-inhibitor (C1Inh). Despite having normal levels of C1Inh, individuals with this form of HAE experience recurrent episodes of swelling in the face, extremities, and airway.