At this time, there is no cure for PLEC-related intermediate epidermolysis bullosa simplex without extracutaneous involvement. However, there are medications and treatments that can help manage the symptoms and reduce the risk of complications. These include topical steroids, antibiotics, and moisturizers to reduce inflammation and itching, and systemic medications such as retinoids and immunosuppressants to reduce blistering. Additionally, physical therapy and occupational therapy can help improve mobility and reduce the risk of skin damage.

1. Family history of PLEC-related intermediate epidermolysis bullosa simplex
2. Genetic mutations in the PLEC gene
3. Exposure to certain environmental factors, such as ultraviolet light, certain medications, and certain chemicals
4. Certain skin conditions, such as atopic dermatitis or psoriasis
5. Certain medical conditions, such as diabetes or HIV/AIDS
6. Certain autoimmune diseases, such as lupus or rheumatoid arthritis

1. Topical treatments:

-Moisturizers
-Topical steroids
-Topical antibiotics
-Topical retinoids
-Topical calcineurin inhibitors

2. Systemic treatments:

-Oral antibiotics
-Oral retinoids
-Oral calcineurin inhibitors
-Systemic immunosuppressants
-Systemic steroids
-Phototherapy
-Gene therapy

1. Mutations in the keratin 5 (K5) or keratin 14 (K14) genes.

2. Inheritance of a single mutated copy of the K5 or K14 gene from one parent.

3. Inheritance of two mutated copies of the K5 or K14 gene from both parents.

4. Spontaneous mutations in the K5 or K14 gene.

The symptoms of PLEC-related intermediate epidermolysis bullosa simplex without extracutaneous involvement include:

- Blistering of the skin, usually on the hands and feet
- Blistering of the palms and soles
- Blistering of the scalp
- Blistering of the mucous membranes
- Hyperkeratosis (thickening of the skin)
- Hyperpigmentation (darkening of the skin)
- Scarring of the skin
- Fragile nails
- Hair loss
- Itching and Burning sensation of the skin

PLEC-related intermediate epidermolysis bullosa simplex without extracutaneous involvement is a rare genetic skin disorder caused by mutations in the PLEC gene. It is characterized by blistering of the skin, usually on the hands and feet, but without any other associated symptoms or complications.