There is no cure for Peutz-Jeghers syndrome, but there are medications and treatments available to help manage the symptoms. These include medications to reduce the risk of cancer, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and proton pump inhibitors (PPIs). Surgery may also be recommended to remove polyps or tumors. Additionally, regular screening tests, such as colonoscopies and endoscopies, can help detect any changes in the gastrointestinal tract.

The primary risk factor for Peutz-Jeghers syndrome is a family history of the disorder. Other risk factors include having a parent or sibling with the disorder, having a family history of gastrointestinal polyps, and having a family history of certain types of cancer.

The primary treatment for Peutz-Jeghers syndrome is regular surveillance and monitoring of the gastrointestinal tract. This includes regular endoscopies and colonoscopies to detect and remove any polyps that may be present. In some cases, surgery may be necessary to remove larger polyps or tumors. Other treatments may include medications to reduce the risk of cancer, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and aspirin. Additionally, lifestyle modifications such as quitting smoking and avoiding alcohol can help reduce the risk of cancer.

Peutz-Jeghers syndrome is caused by a mutation in the STK11 gene. This gene is responsible for producing a protein that helps regulate cell growth and division. The mutation causes the protein to be defective, leading to the development of polyps in the gastrointestinal tract and other organs.

The most common symptoms of Peutz-Jeghers syndrome include:

-Dark spots on the lips, mouth, and/or fingers
-Freckles in the mouth and/or around the eyes
-Gastrointestinal polyps
-Abdominal pain
-Diarrhea
-Rectal bleeding
-Weight loss
-Anemia
-Pancreatic cysts
-Liver cysts
-Gallstones
-Increased risk of certain cancers, including breast, ovarian, and colorectal cancer

Peutz-Jeghers syndrome (PJS) is an inherited disorder characterized by the development of dark spots on the skin and the presence of noncancerous (benign) growths in the gastrointestinal tract. People with PJS have an increased risk of developing certain types of cancer, including breast, ovarian, pancreatic, and colorectal cancer. Other features of PJS may include cysts in the pancreas, polyps in the small intestine, and an increased risk of developing certain types of tumors.