At this time, there is no known cure for persistent polyclonal B-cell lymphocytosis. However, medications such as corticosteroids, immunosuppressants, and monoclonal antibodies may be used to reduce the number of B-cells and help manage symptoms. It is important to speak with your doctor to determine the best treatment plan for your individual situation.

1. Advanced age
2. Immunosuppression
3. HIV infection
4. Chronic viral infections
5. Autoimmune diseases
6. Exposure to certain medications
7. Genetic predisposition
8. Certain types of cancer

1. Observation: In some cases, persistent polyclonal B-cell lymphocytosis may resolve on its own without any treatment.

2. Antibiotics: If an infection is causing the condition, antibiotics may be prescribed to treat the infection.

3. Immunosuppressants: In some cases, immunosuppressants may be prescribed to reduce the number of B-cells in the body.

4. Chemotherapy: Chemotherapy may be used to reduce the number of B-cells in the body.

5. Radiation therapy: Radiation therapy may be used to reduce the number of B-cells in the body.

6. Stem cell transplant: In some cases, a stem cell transplant may be used to replace the abnormal B-cells with healthy ones.

1. Chronic infections, such as HIV, hepatitis B, and hepatitis C
2. Autoimmune diseases, such as lupus and rheumatoid arthritis
3. Certain medications, such as immunosuppressants
4. Certain cancers, such as lymphoma and leukemia
5. Genetic disorders, such as X-linked lymphoproliferative syndrome
6. Radiation exposure
7. Chronic inflammation

The symptoms of Persistent polyclonal B-cell lymphocytosis vary depending on the underlying cause. Common symptoms include fatigue, fever, night sweats, weight loss, and enlarged lymph nodes. Other symptoms may include abdominal pain, chest pain, shortness of breath, and an enlarged spleen.

Persistent polyclonal B-cell lymphocytosis is a condition in which there is an increase in the number of B-cells in the blood. This increase is usually seen in people who have chronic infections or autoimmune diseases. It is not a disease in itself, but rather a sign of an underlying condition.