Parkes Weber syndrome is a rare genetic disorder characterized by the abnormal growth of blood vessels. It is caused by a mutation in the RASA1 gene, which is responsible for controlling the growth of blood vessels. Symptoms of Parkes Weber syndrome include overgrowth of the limbs, enlarged veins, and arteriovenous malformations (AVMs). Treatment typically involves surgery to remove the AVMs and medications to reduce the risk of complications.

The most common symptoms of Parkes Weber syndrome include:
* Abnormal growth of blood vessels (vascular malformations)
* Overgrowth of certain parts of the body (hemihypertrophy)
* Swelling of the limbs
* Varicose veins
* High blood pressure in the lungs (pulmonary hypertension)
* Heart defects
* Kidney problems
* Learning disabilities
* Speech and language delays
* Developmental delays
* Seizures
* Skin discoloration
* Vision problems
* Hearing loss

Parkes Weber syndrome is caused by a mutation in the RASA1 gene. This gene is responsible for controlling the growth of blood vessels. The mutation causes abnormal development of the blood vessels, leading to the symptoms associated with Parkes Weber syndrome.

Treatment for Parkes Weber syndrome is aimed at managing the symptoms and complications associated with the condition. Treatment may include:

1. Surgery: Surgery may be used to close the abnormal blood vessels and reduce the risk of bleeding.

2. Medication: Medications may be used to reduce the risk of blood clots and to control high blood pressure.

3. Physical therapy: Physical therapy may be used to help improve mobility and strength.

4. Occupational therapy: Occupational therapy may be used to help with activities of daily living.

5. Speech therapy: Speech therapy may be used to help with communication.

6. Nutrition: A healthy diet may help to reduce the risk of complications associated with Parkes Weber syndrome.

7. Genetic counseling: Genetic counseling may be recommended for families affected by Parkes

1. Family history of Parkes Weber syndrome
2. Mutations in the RASA1 gene
3. Abnormalities in the blood vessels
4. Exposure to certain medications or toxins during pregnancy
5. Maternal diabetes or obesity during pregnancy

There is no cure for Parkes Weber syndrome, but there are medications and treatments that can help manage the symptoms. These include medications to reduce swelling, physical therapy to help with mobility, and surgery to correct any physical deformities.