Omenn syndrome is a rare, inherited disorder that affects the immune system. It is characterized by a lack of T-cells, which are a type of white blood cell that helps the body fight off infections. Symptoms of Omenn syndrome include skin rashes, enlarged lymph nodes, recurrent infections, and failure to thrive. Treatment typically involves a combination of bone marrow transplantation, immunoglobulin therapy, and other medications.

The main symptoms of Omenn syndrome include:

-Severe combined immunodeficiency (SCID)
-Recurrent infections
-Skin rash
-Enlarged lymph nodes
-Diarrhea
-Failure to thrive
-Liver and/or spleen enlargement
-Anemia
-Low blood cell counts
-Abnormal bone marrow
-Abnormal facial features
-Developmental delays

Omenn syndrome is a rare, inherited disorder caused by mutations in one or more genes. These mutations can be inherited from a parent or can occur spontaneously. The most common gene mutations associated with Omenn syndrome are in the RAG1 and RAG2 genes, which are involved in the development of the immune system. Other gene mutations associated with Omenn syndrome include mutations in the IL2RG, ADA, and DCLRE1C genes.

The primary treatment for Omenn syndrome is hematopoietic stem cell transplantation (HSCT). This is a procedure in which healthy stem cells are transplanted into the patient to replace the defective immune system. Other treatments may include immunoglobulin replacement therapy, high-dose corticosteroids, and other immunosuppressive medications. In some cases, gene therapy may be used to correct the genetic defect that causes Omenn syndrome.

1. Genetic mutations in the RAG1 or RAG2 gene
2. Low levels of T-cells
3. Low levels of B-cells
4. Low levels of natural killer cells
5. Low levels of immunoglobulins
6. Low levels of IgA
7. Low levels of IgM
8. Low levels of IgG
9. Low levels of CD4+ T-cells
10. Low levels of CD8+ T-cells
11. Low levels of CD19+ B-cells
12. Low levels of CD3+ T-cells
13. Low levels of CD16+ NK cells
14. Low levels of CD56+ NK cells
15. Low levels of CD45+ leukocytes
16. Low levels of CD25+ T-cells
17. Low

At this time, there is no cure for Omenn syndrome. Treatment focuses on managing the symptoms and complications of the condition. This may include medications to help with breathing, nutrition, and infections, as well as physical and occupational therapy. Bone marrow or stem cell transplants may be recommended in some cases.