Okihiro syndrome is a rare genetic disorder caused by a microdeletion of the long arm of chromosome 20 (20q13). It is characterized by distinctive facial features, short stature, intellectual disability, and skeletal abnormalities.

The symptoms of Okihiro syndrome due to 20q13 microdeletion vary from person to person, but may include:

-Developmental delay
-Intellectual disability
-Growth delays
-Feeding difficulties
-Speech delays
-Hearing loss
-Seizures
-Heart defects
-Cleft lip and/or palate
-Abnormalities of the hands and feet
-Kidney abnormalities
-Eye abnormalities
-Gastrointestinal problems
-Skin abnormalities
-Behavioral problems

Okihiro syndrome is a rare genetic disorder caused by a microdeletion of the long arm of chromosome 20 (20q13). The exact cause of this microdeletion is unknown, but it is believed to be due to a random error that occurs during the formation of reproductive cells (eggs or sperm) in a parent. This error results in the deletion of a small piece of genetic material from the chromosome, which is then passed on to the child. Other possible causes of Okihiro syndrome include environmental factors, such as exposure to certain chemicals or radiation, or a spontaneous mutation.

1. Physical therapy: Physical therapy can help improve muscle strength, coordination, and balance.

2. Occupational therapy: Occupational therapy can help improve fine motor skills, such as handwriting, and help with activities of daily living.

3. Speech therapy: Speech therapy can help improve communication skills.

4. Behavioral therapy: Behavioral therapy can help with social skills and managing challenging behaviors.

5. Medications: Medications can be used to help manage seizures, anxiety, and other symptoms.

6. Surgery: Surgery may be recommended to correct certain physical abnormalities.

1. Advanced maternal age
2. Family history of chromosomal abnormalities
3. Maternal exposure to certain medications or environmental toxins
4. Maternal diabetes
5. Maternal obesity
6. Maternal smoking
7. Maternal alcohol consumption
8. Maternal use of recreational drugs
9. Maternal infection during pregnancy
10. Advanced paternal age

At this time, there is no known cure for Okihiro syndrome due to 20q13 microdeletion. However, there are medications and therapies that can help manage the symptoms associated with the condition. These include medications to help with seizures, physical and occupational therapy to help with motor skills, speech therapy to help with communication, and behavioral therapy to help with social skills.