Non-epidermolytic palmoplantar keratoderma is a rare skin condition that causes thickening of the skin on the palms of the hands and soles of the feet. It is caused by a mutation in the gene that controls the production of keratin, a protein that helps form the outer layer of the skin. Symptoms of this condition include thick, scaly skin on the palms and soles, as well as pain and itching. Treatment typically involves the use of topical medications and moisturizers to reduce the symptoms.

The symptoms of Non-epidermolytic palmoplantar keratoderma (NEPPK) include thickening of the skin on the palms and soles, which can lead to painful cracking and fissuring. The skin may also become dry, scaly, and itchy. In some cases, the skin may become thickened and hardened, making it difficult to move the fingers and toes. Other symptoms may include nail changes, such as thickening, splitting, and discoloration.

The causes of Non-epidermolytic palmoplantar keratoderma (NEPPK) are not fully understood. However, it is believed to be caused by a combination of genetic and environmental factors. Genetic factors may include mutations in the genes encoding keratin proteins, which are responsible for the formation of the outer layer of the skin. Environmental factors may include exposure to certain chemicals, such as detergents, and certain medications. In some cases, NEPPK may be associated with other medical conditions, such as diabetes or thyroid disease.

1. Topical retinoids: Topical retinoids, such as tretinoin, can be used to reduce the thickness of the skin and improve its appearance.

2. Topical corticosteroids: Topical corticosteroids, such as hydrocortisone, can be used to reduce inflammation and itching.

3. Oral retinoids: Oral retinoids, such as isotretinoin, can be used to reduce the thickness of the skin and improve its appearance.

4. Phototherapy: Phototherapy, such as narrowband UVB, can be used to reduce the thickness of the skin and improve its appearance.

5. Surgery: Surgery may be used to remove thickened areas of skin.

6. Moisturizers: Moisturizers can be used to

1. Genetic predisposition: Non-epidermolytic palmoplantar keratoderma is often inherited in an autosomal dominant pattern, meaning that a single copy of the altered gene is sufficient to cause the disorder.

2. Environmental factors: Exposure to certain chemicals, such as solvents, detergents, and other irritants, may increase the risk of developing Non-epidermolytic palmoplantar keratoderma.

3. Certain medical conditions: People with certain medical conditions, such as diabetes, psoriasis, and thyroid disorders, may be at an increased risk of developing Non-epidermolytic palmoplantar keratoderma.

4. Certain medications: Certain medications, such as lithium, may increase the risk of developing Non-epidermolytic palm

There is no cure for Non-epidermolytic palmoplantar keratoderma, but there are medications that can help manage the symptoms. These include topical corticosteroids, topical retinoids, and oral retinoids. In some cases, laser therapy may be used to reduce the thickness of the skin.