Neuronal intranuclear inclusion disease (NIID) is a rare, inherited neurological disorder that affects the central nervous system. It is characterized by the presence of abnormal inclusions in the nuclei of neurons in the brain and spinal cord. Symptoms of NIID include seizures, intellectual disability, spasticity, and movement disorders. There is currently no cure for NIID, but treatment can help manage symptoms.

The symptoms of Neuronal Intranuclear Inclusion Disease (NIID) vary depending on the severity of the condition, but may include:

- Muscle weakness
- Difficulty walking
- Abnormal gait
- Loss of coordination
- Speech difficulties
- Seizures
- Cognitive impairment
- Visual disturbances
- Abnormal eye movements
- Abnormal reflexes
- Abnormal muscle tone
- Abnormal posture
- Abnormal breathing
- Abnormal heart rate
- Abnormal blood pressure
- Abnormal sweating
- Abnormal temperature regulation
- Abnormal sleep patterns
- Abnormal behavior
- Abnormal appetite
- Abnormal weight gain or loss
- Abnormal hormone levels
- Abnormal liver function tests
- Abnormal kidney function tests
- Abnormal blood sugar levels
- Abnormal cholesterol levels

Neuronal intranuclear inclusion disease (NIID) is a rare, inherited neurological disorder caused by mutations in the gene that encodes the protein ubiquitin-specific protease-2 (USP2). Mutations in this gene lead to the accumulation of abnormal proteins in the nucleus of neurons, resulting in the formation of intranuclear inclusions. These inclusions can cause a variety of neurological symptoms, including seizures, intellectual disability, and movement disorders.

Unfortunately, there is no known cure for Neuronal Intranuclear Inclusion Disease (NIID). Treatment is focused on managing symptoms and providing supportive care. This may include physical therapy, occupational therapy, speech therapy, and medications to help control seizures, muscle spasms, and other symptoms. Additionally, genetic counseling may be recommended for families affected by NIID.

1. Genetic mutation: Neuronal intranuclear inclusion disease is caused by a mutation in the gene that codes for the protein ubiquitin-specific protease-22 (USP22).

2. Age: Neuronal intranuclear inclusion disease is most commonly seen in children and young adults.

3. Gender: Neuronal intranuclear inclusion disease is more common in males than females.

4. Family history: Neuronal intranuclear inclusion disease is more likely to occur in individuals with a family history of the disorder.

Unfortunately, there is no cure for Neuronal Intranuclear Inclusion Disease (NIID). However, medications can be used to manage the symptoms of NIID. These medications may include anticonvulsants, muscle relaxants, and medications to help with sleep disturbances. Additionally, physical and occupational therapy can help to improve mobility and coordination.