Neurofibromatosis type 1 (NF1) is caused by a mutation in the NF1 gene. This mutation can be either a point mutation or an intragenic deletion.

The most common symptoms of Neurofibromatosis type 1 (NF1) due to NF1 mutation or intragenic deletion include:

-Multiple café-au-lait spots (flat, pigmented patches of skin)
-Freckling in the armpits or groin
-Neurofibromas (benign tumors of the nerves and skin)
-Lisch Nodules (benign tumors of the iris)
-Bone deformities
-Learning disabilities
-High blood pressure
-Vision problems
-Headaches
-Seizures

Neurofibromatosis type 1 (NF1) is caused by a mutation in the NF1 gene, which is located on chromosome 17. The mutation can be inherited from a parent or can occur spontaneously. It can also be caused by an intragenic deletion, which is when a portion of the gene is missing.

1. Surgery: Surgery may be used to remove tumors or to reduce the size of tumors that are causing pain or other symptoms.

2. Medication: Medications such as anticonvulsants, antidepressants, and antipsychotics may be used to help manage pain and other symptoms.

3. Radiation Therapy: Radiation therapy may be used to shrink tumors or to reduce the risk of tumor growth.

4. Targeted Therapy: Targeted therapy is a type of treatment that uses drugs to target specific molecules in the body that are involved in the growth and spread of cancer cells.

5. Clinical Trials: Clinical trials are research studies that test new treatments or therapies for safety and effectiveness. Participation in a clinical trial may provide access to new treatments that are not yet available to the general public.

1. Family history of NF1: Individuals with a family history of NF1 are at an increased risk of developing the disorder.

2. Mutation of the NF1 gene: Individuals with a mutation of the NF1 gene are at an increased risk of developing NF1.

3. Intragenic deletion: Individuals with an intragenic deletion of the NF1 gene are at an increased risk of developing NF1.

4. Age: Individuals over the age of 30 are at an increased risk of developing NF1.

5. Gender: Females are more likely to develop NF1 than males.

At this time, there is no cure for Neurofibromatosis type 1 (NF1) due to NF1 mutation or intragenic deletion. However, there are medications that can be used to manage the symptoms of NF1. These medications include anticonvulsants, antipsychotics, and antidepressants. Additionally, physical and occupational therapy can help to improve mobility and reduce pain. Surgery may also be used to remove tumors or to correct physical deformities.