Neurodegenerative syndrome due to cerebral folate transport deficiency (NCTD) is a rare genetic disorder characterized by progressive neurological deterioration due to a deficiency in the transport of folate across the blood-brain barrier. Symptoms of NCTD can include developmental delay, intellectual disability, seizures, and movement disorders. Treatment typically involves folate supplementation and other supportive therapies.

The symptoms of Neurodegenerative syndrome due to cerebral folate transport deficiency can vary depending on the severity of the condition, but may include:

-Developmental delay
-Intellectual disability
-Seizures
-Movement disorders
-Behavioral problems
-Speech and language delays
-Growth delays
-Feeding difficulties
-Vision and hearing problems
-Sleep disturbances
-Skin problems
-Gastrointestinal issues
-Muscle Weakness and spasticity

Neurodegenerative syndrome due to cerebral folate transport deficiency is caused by mutations in the SLC19A3 gene, which encodes a folate transporter protein. This protein is responsible for transporting folate into the brain, and when it is mutated, folate cannot be transported into the brain, leading to a deficiency. This deficiency can lead to a variety of neurological symptoms, including seizures, developmental delays, and movement disorders.

1. Dietary supplementation with folinic acid and/or folinic acid-enriched foods.
2. Vitamin B12 supplementation.
3. Anticonvulsant medications to control seizures.
4. Physical, occupational, and speech therapy to help with motor and cognitive deficits.
5. Medications to help with sleep disturbances.
6. Medications to help with behavioral issues.
7. Genetic counseling and testing.
8. Stem cell therapy.

1. Genetic mutation in the SLC19A3 gene
2. Low levels of folate in the body
3. Low levels of vitamin B12 in the body
4. Exposure to environmental toxins
5. Advanced age
6. Poor nutrition
7. Certain medications
8. Alcohol abuse
9. Head trauma
10. Infections

At this time, there is no known cure for Neurodegenerative syndrome due to cerebral folate transport deficiency. However, there are medications that can help manage the symptoms of the condition. These medications include folinic acid, 5-methyltetrahydrofolate, and leucovorin. Additionally, physical and occupational therapy can help improve motor skills and cognitive functioning.