Neonatal Marfan syndrome is a rare genetic disorder that affects the connective tissue in the body. It is caused by a mutation in the FBN1 gene, which is responsible for producing the protein fibrillin-1. Symptoms of Neonatal Marfan syndrome can include heart defects, skeletal abnormalities, and vision problems. Treatment typically involves medications and surgery to correct any physical abnormalities.

The symptoms of Neonatal Marfan syndrome can vary, but may include:

-Low birth weight
-Abnormal chest shape
-Long, thin fingers and toes
-Joint laxity
-Scoliosis
-High, arched palate
-Widely spaced eyes
-Heart defects
-Kidney abnormalities
-Gastrointestinal problems
-Developmental delays

Neonatal Marfan syndrome is caused by a genetic mutation in the FBN1 gene, which is responsible for producing the protein fibrillin-1. This protein is essential for the formation of connective tissue in the body. Mutations in the FBN1 gene can cause the body to produce an abnormal form of fibrillin-1, leading to the development of Marfan syndrome.

The treatment for Neonatal Marfan syndrome is focused on managing the symptoms and preventing complications. Treatment may include medications to reduce the risk of aortic dissection, physical therapy to improve joint flexibility, and surgery to repair any structural abnormalities. In some cases, medications may be prescribed to reduce the risk of vision loss. In addition, regular monitoring of the heart and aorta is recommended to detect any changes in size or shape.

1. Family history of Marfan syndrome
2. Maternal age over 35
3. Maternal history of aortic dissection
4. Maternal history of aortic aneurysm
5. Maternal history of mitral valve prolapse
6. Maternal history of aortic root dilatation
7. Maternal history of aortic regurgitation
8. Maternal history of aortic valve stenosis
9. Maternal history of Marfanoid features
10. Maternal history of cardiovascular disease
11. Maternal history of connective tissue disorder
12. Maternal history of Ehlers-Danlos syndrome
13. Maternal history of osteogenesis imperfecta
14. Maternal history of scoliosis
15. Maternal history of mitral valve prolapse
16.

At this time, there is no cure for Neonatal Marfan syndrome. However, medications can be used to help manage the symptoms. These medications include beta-blockers, ACE inhibitors, and diuretics. Additionally, physical therapy and occupational therapy can help improve the quality of life for those with Neonatal Marfan syndrome.