NDE1-related microhydranencephaly is a rare neurological disorder caused by mutations in the NDE1 gene. It is characterized by the absence of most of the brain's cerebral hemispheres, leaving only the brain stem and cerebellum intact. Symptoms may include seizures, developmental delays, and intellectual disability.

Symptoms of NDE1-related microhydranencephaly can vary depending on the severity of the condition, but may include:

-Seizures

-Developmental delays

-Growth delays

-Feeding difficulties

-Vision and hearing impairments

-Muscle weakness

-Movement disorders

-Cognitive impairments

-Behavioral problems

-Sleep disturbances

-Respiratory problems

-Gastrointestinal issues

-Skin abnormalities

NDE1-related microhydranencephaly is caused by mutations in the NDE1 gene. This gene is responsible for the production of a protein that helps to regulate the development of the brain. Mutations in this gene can lead to the abnormal development of the brain, resulting in microhydranencephaly.

Treatment for NDE1-related microhydranencephaly is largely supportive and symptomatic. Treatment may include physical therapy, occupational therapy, speech therapy, and nutritional support. Medications may be prescribed to help control seizures, and surgery may be recommended to help reduce the size of the head and improve the appearance of the face. In some cases, a shunt may be placed to help drain excess fluid from the brain.

1. Maternal diabetes
2. Maternal hypertension
3. Maternal infection
4. Maternal smoking
5. Maternal drug use
6. Maternal age
7. Low birth weight
8. Premature birth
9. Placental abruption
10. Umbilical cord complications
11. Fetal distress
12. Fetal hypoxia
13. Fetal anemia
14. Fetal growth restriction
15. Chromosomal abnormalities
16. Congenital malformations

Unfortunately, there is no cure for NDE1-related microhydranencephaly. However, there are medications that can help manage the symptoms associated with the condition. These medications can include anticonvulsants, muscle relaxants, and medications to help with sleep and behavior. Additionally, physical and occupational therapy can help improve motor skills and quality of life.