Nance-Horan Syndrome (NHS) is a rare genetic disorder that affects the eyes, teeth, and facial features. It is caused by a mutation in the NHS gene, which is responsible for the production of a protein called Nance-Horan Syndrome protein (NHS-P). Symptoms of NHS include facial abnormalities, such as a wide-set eyes, a small lower jaw, and a cleft palate. Other symptoms include vision problems, hearing loss, and dental abnormalities. People with NHS may also have intellectual disabilities, seizures, and heart defects. Treatment for NHS is focused on managing the symptoms and may include surgery, medications, and physical and occupational therapy.

The most common symptoms of Nance-Horan Syndrome (NHS) include:

• Abnormal facial features, including a wide-set eyes, a broad nasal bridge, a small lower jaw, and a wide mouth
• Cataracts
• Hearing loss
• Intellectual disability
• Delayed development
• Seizures
• Abnormalities of the hands and feet
• Abnormalities of the teeth
• Abnormalities of the heart and other organs

Nance-Horan Syndrome (NHS) is a rare genetic disorder caused by a mutation in the NHS gene. The mutation affects the development of the eyes, face, and teeth. It is an inherited disorder, meaning it is passed down from parent to child. The exact cause of the mutation is unknown, but it is believed to be due to a combination of genetic and environmental factors.

The main treatment for Nance-Horan Syndrome is to manage the symptoms. This may include regular eye exams, hearing tests, and dental care. Surgery may be necessary to correct any vision or hearing problems. Other treatments may include physical therapy, occupational therapy, speech therapy, and special education. In some cases, medications may be prescribed to help manage the symptoms.

The primary risk factor for Nance-Horan Syndrome is having a parent who carries a mutation in the NHS gene. This mutation is passed down from parent to child in an autosomal recessive pattern. Other risk factors include having a family history of the condition, being of European descent, and being male.

At this time, there is no cure for Nance-Horan Syndrome. However, there are medications that can help manage the symptoms. These include antibiotics to treat eye infections, anti-inflammatory medications to reduce swelling, and medications to reduce the risk of seizures. Additionally, surgery may be recommended to correct any physical abnormalities.