Nager Syndrome is a rare genetic disorder that affects the development of the face, limbs, and other parts of the body. It is caused by a mutation in the SF3B4 gene and is characterized by underdeveloped facial features, including a small jaw, a small nose, and low-set ears. Other features include short stature, webbed fingers and toes, and hearing loss.

The most common symptoms of Nager Syndrome include:

-Craniofacial abnormalities, including a small jaw, a receding chin, and a wide-set nose
-Hearing loss
-Cleft palate
-Cleft lip
-Abnormalities of the hands and feet, including syndactyly (webbed fingers and toes)
-Intellectual disability
-Delayed development
-Feeding difficulties
-Vision problems
-Heart defects
-Kidney abnormalities
-Gastrointestinal problems

Nager Syndrome is a rare genetic disorder caused by a mutation in the SF3B4 gene. This gene is responsible for the production of a protein that helps regulate the development of facial features. The mutation in this gene can cause a variety of physical abnormalities, including a small jaw, a cleft palate, and malformed ears. Other symptoms may include hearing loss, vision problems, and intellectual disabilities.

The treatments for Nager Syndrome vary depending on the individual and the severity of the condition. Treatment may include physical therapy, occupational therapy, speech therapy, orthopedic surgery, and/or hearing aids. In some cases, surgery may be necessary to correct facial deformities. Other treatments may include medications to help with pain, muscle spasms, and seizures. In addition, genetic counseling may be recommended to help families understand the condition and its implications.

1. Family history of Nager Syndrome
2. Mutation in the SF3B4 gene
3. Chromosomal abnormality
4. Exposure to certain environmental toxins
5. Maternal diabetes
6. Maternal obesity
7. Maternal age over 35

There is no cure for Nager Syndrome, but there are medications that can help manage the symptoms. These medications can include muscle relaxants, anticonvulsants, and pain medications. Physical and occupational therapy can also help improve mobility and function.